Tender Details

Country: Canada
Summary: Telemetry for Neurochemical Mechanisms in Depression & Cognition
CAT Ref No: 65943790
Deadline: 13 May 2022
Financier: Self Financed
Purchaser Ownership: Government
Tender Value: Refer Document
Notice Type: Tender
Document Ref. No.: 0000222745
Purchaser's Detail:
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Description:
TELEMETRY FOR NEUROCHEMICAL MECHANISMS IN DEPRESSION & COGNITION
Solicitation Type : RFQ - Request for Qualifications (Formal)
Solicitation Number : 40113-12-RFQ
Location : Canada, Ontario
Purchase Type : Duration: TBD

Description : This Request for Quote (“RFQ”) is an invitation to prospective Proponents to submit Quotes for the provision of Telemetry for Neurochemical Mechanisms in Depression & Cognition, including installation and on-site training. Exposure to stress during puberty can have long-lasting consequences on brain processing, behavior, and future response to stressors, including immune challenges. Lipopolysaccharide (LPS) is a bacterial endotoxin and a component of the outer membrane of gram-negative bacteria. Intraperitoneal administration of LPS mimics the effects of bacterial infections by binding to and activating Toll-like receptor 4 on immune cells and the subsequent cellular cascade leads to the production of cytokines (pro-inflammatory and anti-inflammatory), cyclooxygenase-2, and prostaglandins (PGE2) in the periphery. PGE2 cross the blood brain barrier to act on specific brain regions: Vascular Organ of the Lamina Terminalis and Ventromedial Preoptic area of the Hypothalamus, causing cutaneous vasoconstriction, reduction of sweating, and increased heat production from metabolism of brown adipose tissue. The culmination of these events results in the display of particular sickness-related behaviors, and changes in body tempera...
Documents:

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Telemetry for Neurochemical Mechanisms in Depression & Cognition - Canada Tender

The UNIVERSITY OF OTTAWA, a Government sector organization in Canada, has announced a new tender for Telemetry for Neurochemical Mechanisms in Depression & Cognition. This tender is published on CanadaTenders under CAT Ref No: 65943790 and is categorized as a Tender. Interested and eligible suppliers are invited to participate by reviewing the tender documents and submitting their bids before the deadline on 2022-05-13.

The estimated tender value is Refer Document, and full details, including technical specifications and submission requirements, are provided in the official tender documents. Ensure all submissions meet the criteria outlined to be considered for evaluation.