Tender Details

Country: Canada
Summary: Optical Imaging and Manipulation of Synaptic and Network Dynamics
CAT Ref No: 107496063
Deadline: 18 Oct 2024
Financier: Self Financed
Purchaser Ownership: Government
Tender Value: Refer Document
Notice Type: Tender
Document Ref. No.: 44748-2A-RFP
Purchaser's Detail:
Login to see full purchaser details. Login to see full purchaser details. Login to see full purchaser details. Login to see full purchaser details. Login to see full purchaser details. Login to see full purchaser details. Login to see full purchaser details. Login to see full purchaser details. Login to see full purchaser details.
Login to see details
Description:
Scope:The overall project requires advanced imaging infrastructure used by a team of highly collaborative scientists with complementary and synergistic expertise to: 1) study synaptic and dendritic integrative function in neurons maintained in acute brain slices; 2) identify dendritic, cellular and network strategies in cortex during decision-making tasks in head-fixed awake animals; 3) dissecting the functional roles and connectivity of local inhibitory circuits within the motor cortex during reward-based motor skill learning; 4) deciphering the spatiotemporal relationship of synaptic plasticity with dendritic inhibition during motor skill learning; 5) visualizing and perturbing distinct neuronal ensembles during behavior.This research will highlight basic aspects of strategies used by the brain to learn. It will have a significant impact on the development of therapeutic strategies for counteracting learning and memory deficits as well as motor circuit-related dysfunction associated with stroke, neurodegenerative disease, and traumatic brain injury.General Description: The requested solution needs to allow researchers to optically monitor and manipulate large ensembles of synaptic and neuronal ensembles simultaneously across different cortical layers in acute brain slices and in in vivo awake, head-restrained animals engaged in sophisticated decision-making tasks. The requested system is a microscope allowing for multiphoton imaging and manipulation of synaptic and cellular...
Documents:

If you are registered member, kindly login to view full details of this tender notice:

Optical Imaging and Manipulation of Synaptic and Network Dynamics - Canada Tender

The UNIVERSITY OF OTTAWA, a Government sector organization in Canada, has announced a new tender for Optical Imaging and Manipulation of Synaptic and Network Dynamics. This tender is published on CanadaTenders under CAT Ref No: 107496063 and is categorized as a Tender. Interested and eligible suppliers are invited to participate by reviewing the tender documents and submitting their bids before the deadline on 2024-10-18.

The estimated tender value is Refer Document, and full details, including technical specifications and submission requirements, are provided in the official tender documents. Ensure all submissions meet the criteria outlined to be considered for evaluation.